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Alkaloisds isolated from Aconitum camichaeli debx growing in Ha Giang province

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 Loi Vu Duc, Vung Nguyen Tien

ABSTRACT

The roots of Aconitum carmichaeli Debx. are recognized as a medicinal plant by its anti-inflammatory and analgesic effects. Our phytochemical investigation of the roots led to the isolation of three alkaloids including delcosine (1), fuziline (2), and karacoline (3). Their structures were identified on the basis of NMR, MS, IR spectroscopic analysis and comparison with the published NMR data. Compound 1 was isolated for the first time from this plant.

Objectives

To extract and isolate compounds from the roots of Aconitum carmichaeli Debx growing in Ha Giang province, Vietnam.

Methods

 We use the chromatography column method with different solvent to extract and isolate  compounds. Their structures were identified on the basis of NMR, MS, IR spectroscopic analysis and comparison with the published NMR data.

Results

From the ethanol extract of the daughter roots of A. carmichaeli Debx. collected in Ha Giang province, Vietnam we have isolated three alkaloids: delcosine (1), fuziline (2) and karacoline (3).

Conclusions

In the alkaloids isolated, delcosine was isolated for the first time from A. carmichaeli Debx.

Keywords

Aconitum carmichaeli, alkaloid, delcosine, fuziline, karacoline

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